Vagal KATPchannels are the key to ghrelin's orexigenic action
نویسندگان
چکیده
منابع مشابه
Vagal plasticity the key to obesity
In their commentary on our article in Molecular Metabolism [1], Page et al. [2] propose the concept that leptin can act as a “double agent” e inhibiting food intake in lean animals, but promoting food intake in obese animals. This hypothesis stems from our finding that knocking out leptin receptor in vagal afferent neurons increases food intake and weight gain in low fat fed mice, while prevent...
متن کاملHypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic response to ghrelin involves specific inhibition of fatty acid biosynthesis i...
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Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti-related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the hypothalamus (ARC). However, there is a paucity of data about the poss...
متن کاملPotentiation of cardiac vagal action by cold.
The effect of cold on vagal action at the heart was studied in sheep, dogs and an isolated guinea pig atrial preparation. During cardiac output measurements in unanaesthetized sheep, by the thermodilution method, bradycardia was evoked on injection of cold indicator in eight of 12 sheep studied. This bradycardia was consistently evoked when blood pressure was increased, but not at normal blood ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2015
ISSN: 0022-3751
DOI: 10.1113/jp271396